Letrozole: Uses, Interactions, Mechanism of Action DrugBank Online

Letrozole: Uses, Interactions, Mechanism of Action DrugBank Online

Costs of prescription drugs can vary depending on many factors. These factors include what your insurance plan covers and which pharmacy you use. You shouldn’t take letrozole while you’re pregnant or breastfeeding.

  • If your dose is different, do not change it unless your doctor tells you to do so.
  • This list doesn’t contain all types of drugs that may interact with letrozole oral tablets.
  • In the adjuvant trial (BIG 1-98) the incidence of bone fractures at any time after randomization was 14.7% for letrozole and 11.4% for tamoxifen at a median follow-up of 96 months.

Comparisons of the incidence of adverse reactions revealed no significant differences between the high and low dose https://www.dapsides.it/us-anabolicsteroids-usa-com/surge-in-online-sales-bodybuilders-in-the-usa/ groups in either study. During treatment or within 30 days of stopping treatment (median duration of treatment 60 months) the incidence of cardiovascular events was 9.8% for letrozole and 7.0% for placebo. Letrozole lowers the levels of the female sex hormone oestrogen in the body. These breast cancers are called hormone sensitive or hormone receptor positive. This information should not be used to decide whether or not to take letrozole or any other medicine.

Side effects of letrozole (Femara)

Call your doctor right away if you have an allergic reaction to letrozole oral tablets. But if you think you’re having a medical emergency, call 911 or your local emergency number. In studies, joint pain was a common side effect of letrozole. Letrozole and other drugs in the same group of medications commonly cause joint pain and stiffness.

Precautions while using letrozole

You will need frequent medical tests, and your bone mineral density may also need to be checked. The results for the study comparing letrozole to aminoglutethimide (AR/BC3), with a minimum follow-up of 9 months, are shown in Table 18. Confirmed objective tumor response (complete response plus partial response) was the primary endpoint of the trials.

For example, it may be possible to switch to another aromatase inhibitor to see if your pain improves, or some people might be offered the drug tamoxifen as an alternative. You should only take this drug if you have been through your menopause. When you first go through the menopause there can still be a chance that you could become pregnant. It is important to not to become pregnant while you are having treatment and for a few months afterwards. So, even if you have had your menopause, talk to your doctor or nurse about effective contraception before starting treatment. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems.

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